\[\frac{\sqrt{25a^{9}} \cdot \sqrt{16b^{8}}}{\sqrt{a^{5}b^{8}}} = \frac{5a^{4}\sqrt{a} \cdot 4b^{4}}{a^{2}b^{4}\sqrt{a}} = 20a^{2};\]
\[a = 4:\]
\[20a^{2} = 20 \cdot 4^{2} = 20 \cdot 16 = 320.\]