\[a_{1} = 8;\ \ a_{2} = 4:\]
\[d = a_{2} - a_{1} = 4 - 8 = - 4.\]
\[S_{16} = \frac{2a_{1} + 15d}{2} \cdot 16 = 8 \cdot (2 \cdot 8 - 4 \cdot 15) =\]
\[= 8 \cdot (16 - 60) = 8 \cdot ( - 44) =\]
\[= - 352.\]
\[Ответ:\ - 352.\]